Two 'Golden Ratio' indices in fragment-based drug discovery.

A Class of Convergent Series with Golden Ratio Based on Fibonacci Sequence

In this article, a class of convergent series based on Fibonacci sequence is introduced for which there is a golden ratio (i.e. $frac{1+sqrt 5}{2}),$ with respect to convergence analysis. A class of sequences are at first built using two consecutive numbers of Fibonacci sequence and, therefore,  new sequences have been used in order  to introduce a  new class of series. All properties of the se...

Fragment-based Binding Efficiency Indices in Bioactive Molecular Design: A Computational Approach to BACE-1 Inhibitors

One of the most important targets in Alzheimer disease is Beta site amyloid precursor protein cleaving enzyme-1 (BACE-1). It is a membrane associated protein and is one of the main enzymes responsible for amyloid β (Aβ) production. Up to now, a considerable number of peptidic and non-peptidic inhibitors of BACE-1 have been developed. Recently, small molecule BACE-1 inhibitors have attracted the...

Fragment-based Binding Efficiency Indices in Bioactive Molecular Design: A Computational Approach to BACE-1 Inhibitors

One of the most important targets in Alzheimer disease is Beta site amyloid precursor protein cleaving enzyme-1 (BACE-1). It is a membrane associated protein and is one of the main enzymes responsible for amyloid β (Aβ) production. Up to now, a considerable number of peptidic and non-peptidic inhibitors of BACE-1 have been developed. Recently, small molecule BACE-1 inhibitors have attracted the...

The reproductive biology of golden barb (Barbus luteus Heckel, 1843) in Maroon River, Iran

Golden barb (Barbus luteus) is one of the species in south and southwest of Iran which is greatly favorable to residents of the region. Unfavorable ecological conditions in habitat of this species and overfishing have led to reduction of the population of golden barb. Therefore, to restore the natural stock of this species, identifying its reproductive cycle associated with its habitat is of a ...

***Removed from the Issue*** Application of Cell-Based Assay Systems for the Early Screening of Human Drug Hepatotoxicity in the Discovery Phase of Drug Development